Santiago Schnell
Professor
Appointments
Provost
Professor of Mathematics
Adjunct Professor of Biochemistry & Cell Biology
Adjunct Professor of Biomedical Data Science
Area of Expertise
mathematical and theoretical biology,
quantitative biology,
enzyme kinetics,
measurement and standardization,
design of experiments
Biography
Santiago Schnell is the Provost, Professor of Mathematics, and Adjunct Professor of Biochemistry & Cell Biology and Biomedical Data Science at Dartmouth. He previously served as the William K. Warren Foundation Dean of the College of Science at the University of Notre Dame, where he was also Professor of Biological Sciences and Applied & Computational Mathematics & Statistics.
Schnell investigates the molecular continuum between physiological function and disease, with a focus on developing rigorous, reproducible measurement and modeling methods in the biomedical sciences. He is internationally recognized for his contributions to enzyme kinetics, including the development of the Schnell-Mendoza equation. He is a member of the American Academy of Sciences and Letters, an Emerging Leader in Health and Medicine of the U.S. National Academy of Medicine, and recipient of the Arthur Winfree Prize.
He is also a Fellow of the Royal Society of Chemistry, the American Association for the Advancement of Science, the Society for Mathematical Biology, the Latin American Academy of Sciences, the Royal Society of Medicine, and the Royal Society of Biology. In addition, he has served on the editorial boards of ten leading scientific journals.
Education
License in Biology, Universidad Simón Bolívar, Venezuela (Awarded: 24 Jan 1997)
Doctor of Philosophy (Mathematics), University of Oxford, UK (Awarded: 8 Nov 2003)
Publications
● S. Schnell and C. Mendoza (1997). Closed form solution for time-dependent
enzyme kinetics. Journal of Theoretical Biology 187, 207-212.
● S. Schnell and T. E. Turner (2004). Reaction kinetics in intracellular
environments with macromolecular crowding: simulations and rate laws.
Progress in Biophysics and Molecular Biology 85, 235-260.
● C. I. Sandefur and S. Schnell (2011). A model of threshold behavior reveals
rescue mechanisms of bystander proteins in conformational diseases.
Biophysical Journal 100, 1864-1873.
● K. D. Walton, M. Whidden, Å. Kolterud, S. K. Shoffner, M. J. Czerwinski, J.
Kushwaha, N. Parmar, D. Chandhrasekhar, A. M. Freddo, S. Schnell and D. L.
Gumucio (2016). Villification in the mouse: Bmp signals control intestinal villus
patterning. Development 143, 427-436.
● W. Stroberg and S. Schnell (2016). On the estimation errors of Km and V from
time-course experiments using the Michaelis-Menten equation. Biophysical
Chemistry 219, 17–27.
● W. Stroberg, H. Atkin, Y. Savir and S. Schnell (2018). How to design an optimal
sensor network for the unfolded protein response. Molecular Biology of the Cell
29, 3052–3062.
● W. Stroberg and S. Schnell (2018) Do cellular condensates accelerate
biochemical reactions? Lessons from microdroplet chemistry. Biophysical Journal
115, 3-8.
● S. Pitchiaya, M. D.A. Mourao, A. Jalihal, L. Xiao, X. Jiang, A. M. Chinnaiyan, S.
Schnell and N. G. Walter (2019). Dynamic recruitment of single RNAs to
processing bodies depends on RNA functionality. Molecular Cell 74, 521-533.
● J. Cavataio and S. Schnell (2021). Interpreting SARS-CoV-2 fatality rate
estimates: A case for introducing standardized reporting to improve
communication. Mathematical Biosciences 333, 108545.
● S. Lauterbach, H. Dienhart, J. Range, S. Malzacher, J.-D. Spöring, D Rother, M.
Filipa Pinto, P. Martins, C. E. Lagerman, A. S. Bommarius, A. V. Høst, J. M.
Woodley, S. Ngubane, T. Kudanga, F. T. Bergmann, J. M. Rohwer, D. Iglezakis,
A. Weidemann, U. Wittig, C. Kettner, N. Swainston, S. Schnell, J. Pleiss (2023).
EnzymeML at work: seamless data flow and modelling of enzymatic data. Nature
Methods 20, 400–402.
For a full and continuously updated list of publications, please visit Google Scholar.
Selected Works & Activities
● President-elect, President and Past-President, Society for Mathematical Biology,
2014-2018
● Member of the "Standards for Reporting Enzymology Data" (STRENDA)
Commission, 01/2016-present
● Editorial Board, Current Opinion in Systems Biology, 01/2016-present
● Editorial Board, Biophysical Chemistry, 10/2016-present
● Editorial Advisory Board, Biomolecular Concepts, 07/2019-present
● Editorial Board, Journal of Theoretical Biology, 02/2019-present
● Editorial Board, Scientific Data, 05/2023-present
● Editorial Advisory Board, Mathematical Biosciences, 07/2023-present
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