Elizabeth F. Smith

Appointments

Dean of the Faculty of Arts and Sciences

Paul M. Dauten, Jr. Professor of Biological Sciences

Area of Expertise

cell biology,

Molecular biology,

cell motility,

ciliary assembly and motility

Biography

Elizabeth F. Smith, the Paul M. Dauten Jr. Professor of Biological Sciences, has served as dean of the Faculty of Arts and Sciences since 2017. She leads Dartmouth's largest academic unit, overseeing its educational policies, curriculum, and all matters relating to the effectiveness, development, and wellbeing of more than 600 faculty members. Smith was previously associate dean of the sciences and has also served as chair of the Department of Biological Sciences. An accomplished research scientist, she has published papers in leading journals and received grant support from institutions including the American Cancer Society, the National Institutes of Health, the National Science Foundation, and the March of Dimes Foundation.

Educated in the liberal arts tradition at Agnes Scott College, Smith went on to earn a Ph.D. in cell and developmental biology from Emory University. Before joining the Dartmouth faculty as an assistant professor in 1998, she spent six years at the University of Minnesota, where she received a prestigious American Cancer Society fellowship for her post-doctoral work in genetics and cell biology. Smith was named a full professor at Dartmouth in 2010. She served as chair of biological sciences for three years, beginning in 2012, before being named the Paul M. Dauten Jr. Professor of the Biological Sciences in 2014.

Education

B.A. Agnes Scott College

Ph.D. Emory University

Publications

Lin, J., Le, V., Augsperger, K., Tritschler, D., Bower, R., Fu, G., Perrone, C., O'Toole, E.T., VanderWaal Mills, K., Dymek, E.E., Smith, E.F., Nicastro, D. and M.E. Porter (2019) FAP57/WDR65 targets assembly of a subset of inner arm dyneins and connects to regulatory hubs in cilia. Molecular Biology of Cell, 2019 Oct 1;30(21):2659-2680. doi: 10.1091/mbc.E19-07-0367. Epub 2019 Sep 4. PMID: 31483737

Dymek, E.E., Lin, J., Fu, G., Porter, M.E., Nicastro, D. and E.F. Smith (2019) PACRG and FAP20 form the inner junction of axonemal doublet microtubules and regulate ciliary motility. Molecular Biology of the Cell, 2019 Jul 15;30(15):1805-1816. doi: 10.1091/mbc.E19-01-0063. Epub 2019 May 22. PMID: 31116684

Fu, G., Zhao, L., Dymek, E.E., Hou, Y., Song, K, Phan, N., Shang, Z., Smith, E.F., Witman, G., Nicastro, D. Structural organization of the C1a-e-c supercomplex within the ciliary central apparatus. (submitted)

Loreng, T.D. and E.F. Smith. (2017) The central apparatus of cilia and eukaryotic flagella. In Cilia and Flagella. Wallace Marshall ed. Cold Spring Harbor Laboratory Press. 9(2)

Mizuno, K., E.E. Dymek and E.F. Smith. (2016) Microtubule binding protein PACRG plays a role in regulating specific ciliary dyneins during microtubule sliding. Cytoskeleton.Dec;73(12):703-711. doi: 10.1002/cm.21340.

Vasudevan, K.K., Song, K., Alford, L.M., Sale, W.S., Dymek, E.E., Smith, E.F., Hennessey, T., Joachimiak, E., Urbanska, P., Wloga, D., Dentler, W., Nicastro, D. and J. Gaertig. (2015) FAP206 is a microtubule-docking adapter for ciliary radial spoke 2 and dynein c. Molecular Biology of the Cell. Feb 15;26(4):696-710.

Wren, K.N., Craft, J.M., Tritschler, D., Schauer, A., Patel, D.K., Smith, E.F., Porter, M.E., Kner, P., and K.F. Lechtreck. (2013) A differential cargo-loading model of ciliary length regulation by IFT. Current Biology. Dec 16;23(24):2463-71.

DiPetrillo, C. and E.F. Smith. (2013) Methods for analysis of calcium / calmodulin signaling in cilia and flagella. Methods in Enzymology, 524: 37-57.

Dymek, E.E., Heuser, T., Lin, J., Smith, E.F. and D. Nicastro. (2012) The CSC connects three major axonemal complexes involved in dynein regulation. Molecular Biology of the Cell 23(16):3143-55

DiPetrillo, C. and E.F. Smith. (2011) The Pcdp1 complex coordinates the activity of dynein isoforms to produce wild-type ciliary motility. Molecular Biology of the Cell 22(23):4527-38 .

Brown J.M., DiPetrillo, C. , Smith, E.F. and G.B. Witman. (2012) A FAP46 mutant provides new insights into the function and assembly of the C1d complex of the ciliary central apparatus. Journal of Cell Science 125(16):3904-13

Dymek, E.E. and E.F. Smith. (2012) PF19 encodes the p60 catalytic subunit of katanin and is required for assembly of the flagellar central apparatus in Chlamydomonas. J. Cell Science 125(Pt 14):3357-66

Goduti, D., and E.F. Smith. (2012) Analyses of functional domains within the PF6 protein of the central apparatus reveal a role for PF6 sub-complex members in regulating flagellar beat frequency. Cytoskeleton 69(3):179-94

DiPetrillo, C. and E.F. Smith. (2011) The Pcdp1 complex coordinates the activity of dynein isoforms to produce wild-type ciliary motility. Molecular Biology of the Cell 22(23):4527-38

Dymek, E.E., Heuser, T., Nicastro, D. and E.F. Smith. (2011) The CSC is required for complete radial spoke assembly and wild-type ciliary motility. Molecular Biology of the Cell 22(14):2520-31

Smith, E.F. and R. Rohatgi. (2011) Cilia 2010: The surprise organelle of the decade. Science Signaling. 4:55 mr1.

Straschil, U., Talman, A., Ferguson, D., Bunting, K., Xu, Z., Bailes, L., Coates, J., Holder, T., Smith, E.F. and R. Tewari. (2010) The Armadillo repeat protein PF16 is essential for flagellar structure and function in Plasmodium male gametes. PLoS ONE . Vol. 5:10 e12901

DiPetrillo, C., and E.F. Smith. (2010) Pcdp1 is a central apparatus protein that binds Ca 2+ -calmodulin and regulates ciliary motility. Journal of Cell Biology 189(3):601-612

Contact

Elizabeth.F.Smith@Dartmouth.EDU

646-3999

226 Life Sciences Center

HB 6044

Departments

Biological Sciences

Institutes

Dean of Faculty