Dean R. Madden

Academic Appointments
  • Professor of Biochemistry and Cell Biology

  • Vice Provost for Research

  • Director, Dartmouth COBRE Institute for Biomolecular Targeting

  • Director, DartCF -- the Dartmouth Cystic Fibrosis Research Center

Professional Interests:

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(603) 646-5197
HB 7200


  • A.B. Physics, Harvard 1985
  • Ph.D. Biophysics, Harvard 1992

Selected Publications

  • Selected Publications:


    Specificity in PDZ-peptide interaction networks: Computational analysis and review.
    Amacher JF, Brooks L, Hampton TH, Madden DR
    J Struct Biol X. 2020;4:100022. doi: 10.1016/j.yjsbx.2020.100022. Epub 2020 Mar 7.
    PMID: 32289118

    Computational Analysis of Energy Landscapes Reveals Dynamic Features That Contribute to Binding of Inhibitors to CFTR-Associated Ligand.
    Holt GT, Jou JD, Gill NP, Lowegard AU, Martin JW, Madden DR, Donald BR
    J Phys Chem B. 2019 Dec 12;123(49):10441-10455. doi: 10.1021/acs.jpcb.9b07278. Epub 2019 Nov 27.
    PMID: 31697075

    Nanobody-based binding assay for the discovery of potent inhibitors of CFTR inhibitory factor (Cif).
    Vasylieva N, Kitamura S, Dong J, Barnych B, Hvorecny KL, Madden DR, Gee SJ, Wolan DW, Morisseau C, Hammock BD
    Anal Chim Acta. 2019 May 30;1057:106-113. doi: 10.1016/j.aca.2018.12.060. Epub 2019 Jan 9.
    PMID: 30832908

    Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain.
    Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR
    Biosci Rep. 2018 Aug 31;38(4) pii: BSR20180231. doi: 10.1042/BSR20180231. Epub 2018 Jul 6.
    PMID: 29472314

    An epoxide hydrolase secreted by Pseudomonas aeruginosa decreases mucociliary transport and hinders bacterial clearance from the lung.
    Hvorecny KL, Dolben E, Moreau-Marquis S, Hampton TH, Shabaneh TB, Flitter BA, Bahl CD, Bomberger JM, Levy BD, Stanton BA, Hogan DA, Madden DR
    Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L150-L156. doi: 10.1152/ajplung.00383.2017. Epub 2017 Oct 5.
    PMID: 28982736

    Optimization of the process of inverted peptides (PIPEPLUS) to screen PDZ domain ligands.
    Seisel Q, Radisch M, Gill NP, Madden DR, Boisguerin P
    Bioorg Med Chem Lett. 2017 Jul 15;27(14):3111-3116. doi: 10.1016/j.bmcl.2017.05.045. Epub 2017 May 15.
    PMID: 28549735

    Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase.
    Hvorecny KL, Bahl CD, Kitamura S, Lee KSS, Hammock BD, Morisseau C, Madden DR
    Structure. 2017 May 2;25(5):697-707.e4. doi: 10.1016/j.str.2017.03.002. Epub 2017 Apr 6.
    PMID: 28392259

    The CFTR trafficking mutation F508del inhibits the constitutive activity of SLC26A9.
    Bertrand CA, Mitra S, Mishra SK, Wang X, Zhao Y, Pilewski JM, Madden DR, Frizzell RA
    Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L912-L925. doi: 10.1152/ajplung.00178.2016. Epub 2017 Mar 30.
    PMID: 28360110

    The cif Virulence Factor Gene Is Present in Isolates From Patients With Pseudomonas aeruginosa Keratitis.
    Bahl CD, St Laurent JD, Karthikeyan RS, Priya JL, Prajna L, Zegans ME, Madden DR
    Cornea. 2017 Mar;36(3):358-362. doi: 10.1097/ICO.0000000000001132.
    PMID: 28079684

    Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators.
    Flitter BA, Hvorecny KL, Ono E, Eddens T, Yang J, Kwak DH, Bahl CD, Hampton TH, Morisseau C, Hammock BD, Liu X, Lee JS, Kolls JK, Levy BD, Madden DR, Bomberger JM
    Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):136-141. doi: 10.1073/pnas.1610242114. Epub 2016 Dec 15.
    PMID: 27980032